ISSN: 2456-4494

                   Volume 1, Issue 1

Welcome to IJPRA! International Journal of Pharmaceutical Research and Applications

Current Issue (Volume 01 - Issue 01) (Oct. 2016)


Title:
Impact Of Agnihotra On Antibiotic Properties Of Piper Nigrum
Authors:
P.K. Mishra
Source:
International Journal of Pharmaceutical Research and Applications, pp 01 - 08, Vol 01 - No. 01, 2016
Abstract:

Piper nigrum L.is an important medicinal plant having wide applications in Ayurveda as antibiotic. Experimentally, extract of Piper nigrum extract has proved effective on both gram -' ve as well as gram +'ve bacteria. Agnihotra therapy is another noteworthy systems of treatment of various diseases where fume of some select plant twig clarified butter and pinch of rice, effectively control growth of disease causing bacteria. In present study combined impact of plant extract and Agnihotra on growth of some pathogenic bacteria was studied. It was proved that Agnihotra on growth of some pathogenic bacteria was studied. It was proved that Agnihotra conclusively help in controlling growth of pathogenic bacteria. Hence Agnihotra treatment along with extract of Piper nigrum is suggested.

Keywords:
Agnihotra, Antibacterial activity, Piper nigrum
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Title:
200 Kashmiri Patients of osteoarthritis Knee Were Studied And Free Drug Combination Versus Fixed Dose Combination of aceclofenac and Diacerin Were assessed For analgesic Efficacy,Safety and Compliance.
Authors:
S.Anupama1, K.Harinath Reddy2, S.Chandrakanth
Source:
International Journal of Pharmaceutical Research and Applications, pp 07 - 09, Vol 01 - No. 01, 2016
Abstract:
The ever-expanding aging population expects and deserves a fulfilling and active life, with low dependence on "managed care". This requires a healthy and well- functioning musculoskeletal system. However, age-related musculoskeletal diseases are a major cause of global morbidity, and result in high costs for health and social care system. Advancing age is a major risk factor for degenerative joint disease. Osteoarthritis (OA) is a degenerative disease resulting from a group of mechanical abnormalities involving joints, articular cartilage and subchondral bone. Osteoarthritis is derived from Greek words "Osteo" meaning the bone, "Ortho" meaning joints and "Itis" which means inflammation. The clinical manifestations in OA are gradual development of joint pain, swelling, instability, stiffness and loss of motion (Louthrenoo W, et al. 2007).The joints most commonly affected are the knees, hip and those of the hand and spine. OA has gradual onset, and symptoms usually don't appear until around the age of 45 to 50 years . Evidences suggest that inflammation events are outcome of intervention of polymorphonuclear leucocytes that release lysosomal enzymes and oxygen free radicals. This results in increased articular cartilage destruction, joint pain, stiffness and limitation of movement (Dieppe p 1978). In OA subchondral osteoblasts have abnormal phenotype, elevated alkaline phosphatase, increased release of osteocalcin, reduced parathyroid hormone and PGE2 dependent cAMP formation, elevated Urokinase plasminogen, IGF-1 and altered collagen metabolism.(Hilal G, et al. 1998, Mansell JP, et al.1998 , Lajeunesse D, et al.1999.).These disease cells produce more IL-6 and PGE-2 than normal.
Keywords:
VHDL, AMBA Bus, Microcontroller.
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Title:
Towards a bright future for an excellent medical care of patients with diabetes in Sudan
Authors:
Awad Mohamed Ahmed1, Walid G. Babikr2, Hatem Mohamed3
Source:
International Journal of Pharmaceutical Research and Applications, pp 30 - 32, Vol 01 - No. 01, 2016
Abstract:
What is Diabetes Mellitus disease?Diabetes mellitus is a chronic disease (i.e. accompanies the patient for life) caused by the lack or shortage of secretion or the lack of effectiveness of insulin hormone produced by specialized cells in the pancreas. The basic function of insulin is to enable the body to make use of sugar as a fuel necessary for different activities and metabolic processes, so in the case of lack of insulin the body does notbenefit optimally from sugar leading to the accumulation of large quantities in the blood. The accumulation of sugar leads instantly to symptoms such as increasedurination, thirst and the feeling of tiredness, while in the long term it leads to diabetes complications such as chronic arteriosclerosis, renal failure, blindness, heart disease and limb amputation.
Keywords:
Trisubstituted purine, carboxamide, antimicrobial activity, phosphorous oxychloride
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Title:
Influence of Circadian Rhythm In Radiation Induced Mucositis In Head And Neck Malignancies
Authors:
Dr. Vipin George Kuriakose *, Dr. Aravindh Sivanandan Anand, Dr. Krishnannair Jayakumar, Dr.Anand Radhakrishnan, Dr. Suma Susan Meloot
Source:
International Journal of Pharmaceutical Research and Applications, pp 33-37, Vol 01 - No. 01, 2016
Abstract:
INTRODUCTION: In India , more than 60 % of the head and neck malignancies present as locally advanced disease. Chemoradiation has been the main stay of treatment for the past three decades. In spite of the multimodality treatment, normal tissue toxicity in the form of mucositis has been a limiting factor.MATERIALS AND METHODS: We investigated the plausible impact of circadian rhythm of normal mucosa to the development and severity of mucositis, based on the timing of radiation delivery in patients receiving radiation treatment in head and neck malignancies. We analysed the data of 142 patients of histologically proven squamous cell carcinoma of the head and neck sites ( stage II to IVA ) , treated from January 2014 who underwent radical external beam radiation therapy (EBRT) to a dose of 60 – 66 Gy in 30 – 33 fractions.. All the patients were treated in a cobalt teletherapy unit , with lateral parallel pair ( 60 -66 Gy/33 # ) and low anterior neck ( 50 Gy /25 #) radiation fields.
Keywords:
Circadian rhythm, Chronotherapy, morning versus evening RT, head and neck cancers
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Title:
Stability Indicating Analytical Method Development, Validation, Method Transfer And Impurity Profile (Related Substances) of 2,4-Dihydroxy-5-Fluoropyrimidine by Liquid Chromatography
Authors:
S.Imam Pasha1*, Dr. Mohd Ibrahim2 , Dr. V.Murli Balram1
Source:
International Journal of Pharmaceutical Research and Applications, pp 13-59, Vol 01 - No. 01, 2016
Abstract:
Stability indicating liquid chromatographic method was developed for related substances [(Pyrimidine-2,4,6 (1H,3H,5H)-trione ,Dihydropyrimidine-2,4,5(3H)-trione ,Uracil,5-Methoxy Uracil, 5-Chloropyrimidine-2,4(1H,3H)-dione)] of 2,4-dihydroxy-5-fluoro pyrimidine , validation was performed on higher presentation i.e. 5 g/100 mL by using Column dimensions of 250mm, 5μm (YMC Pack ODS AQ) with the Flow rate of 1.0 mL/min at Wavelength of 266 nm by Injecting Volume of 20 μL by maintain Run time of 30 minutes.
Keywords:
DNA gyrase, Quinoline-2-one derivatives (Q3), Clinical Pseudomonas aeruginosa PA31.
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Title:
Effect of a new Quinoline-2-one Derivatives( Compound 3) onPurified DNA gyrase from clinical isolatePseudomonas aeruginosaPA31
Authors:
EssamFadel Al-Jumaily, *1Abdal- Kader SaeedLatif, 1Redha Al-Bayati2
Source:
International Journal of Pharmaceutical Research and Applications, pp 46-52, Vol 01 - No. 01, 2016
Abstract:
The aim of this study to evaluate Study of new Quinoline -2-one derivatives (Q3) and application of the molecule on the DNA gyrase which purified from clinical Pseudomonas aeruginosa PA31.Methods: DNA gyrase enzyme was purified from clinical Pseudomonas aeruginosa PA31 with 70% saturation of ammonium sulphate then DEAE-cellulose column with final stage gel filtration. Results:Purified DNA gyrase showed activity on agarose gel against catenated DNA. Synthesized compound (Q3) was chosen for inhibition studies with purified enzyme, compound (Q3) showed full inhibition against purified DNA gyrase at concentration (1000 mg/ml) on agarose gel.Conclusion:Invitro showed that compound (Q3) has highest functional score against DNA gyrase.
Keywords:
DNA gyrase, Quinoline-2-one derivatives (Q3), Clinical Pseudomonas aeruginosa PA31.
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Title:
Composition of the Daily Food Ration in Ivory Coast
Authors:
Drogba Alexis Sahoré 1*; Olga Yolande Aké Ako2; Joachim Levry Abouattier3
Source:
International Journal of Pharmaceutical Research and Applications, pp 60-64, Vol 01 - No. 01, 2016
Abstract:
Food products such as yam, cassava, plantain, rice and maize are an important part of food in Ivory Coast. These products are high in carbohydrates and their consumption only covers the energy needs of the population. It is therefore important to provide other foods rich in proteins, lipids and minerals in the daily diet to meet the food needs of this population.
Keywords:
Food products, Carbohydrates, Proteins, Minerals, Daily diet, Population
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Title:
Screening the Antioxidant activity of Trigonella foenum graecum Seeds
Authors:
Rashmi Yadav; Partha Chowdhury
Source:
International Journal of Pharmaceutical Research and Applications, pp 60-64, Vol 01 - No. 01, 2016
Abstract:
This study was undertaken to examine the antioxidant activity of methanolic extract of seeds of Trigonella foenum-graecum seeds using DPPH free radical scavenging assay. The IC50 (The concentration of sample required to scavenge 50% of DPPH free radical) was calculated by plotting graph between % inhibition vs concentration. The Ascorbic acid was used as standard antioxidant in comparison to methanolic extract of Trigonella foenum-graecum. The IC50 value of extract and Ascorbic acid was found to be 3.24 μg/ml whereas IC50 value of methanolic extract was found to be 1.98 μg/ml. This suggests that methanolic extract of Fenugreek seeds had potent antioxidant activity.
Keywords:
Trigonella foenum-graecum, DPPH assay, IC50 value, Antioxidant activity
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