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Volume 02 - Issue 01 (Jan. 2017)

Title: Design Development and Preparation of Rosiglitazone microcapsules for control release drug delivery
Authors: Bhabani Shankar Nayak || P. Ellaiah || Suchismita Pani || Monalisa Nayak || Dhruba Sarkar
Source: International Journal of Pharmaceutical Research and Applications, pp 01-09, Vol 02 - No. 01, 2017
Abstract: Background: Rosiglitazone is thiazolidinediones group of drug which decreases blood sugar by activation of the peroxisome proliferator-activated receptors. Aim: The study aimed to design and prepare rosiglitazone microcapsule. Methods: The rosiglitazone microcapsule formulations (F1 to F8) were prepares by ionic gelation technique using carbopol – 934, hydroxy propyl methyl cellulose and sodium carboxy methyl cellulose as rate controlling polymer in different ratios of 1:1, 1:2 and 1:2.5 (Drug: polymer). The drug polymer compatibility was studied using FTIR and DSC techniques. The prepared microcapsule were evaluated for yield, particle size, shape (SEM study), wall thickness, flow property, drug content, loose surface crystal study, swelling index, percentage moisture loss, in vitro drug release and kinetic studies............
Keywords: Diabetes, Rosiglitazone, microcapsules, mucoadhesive.
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Title: Ameliorative Effect ofMoringaoleifera Leaves Extract on the Intracranial Auditory Relay Centre (Inferior Colliculus) of Male Albino Wistar Rats with Quinine Induced Toxicity
Authors: Idorenyin Udo Umoh || Akpan Udo Ekanem || Utibe Evans Bassey || Abasifreke Lawrence Ufot
Source: International Journal of Pharmaceutical Research and Applications, pp 10-15, Vol 02 - No. 01, 2017
Abstract: Ethno-pharmacological use of Moringaoleifera (MO) leaf is supported by the reported presence of rich antioxidants and phytochemicals. The effect of administration of quinine and Moringaoleifera leaf ethanolic extract was investigated using thirty-five (35) albino Wistar rats weighing between 180 – 200 grams. The rats were divided into seven groups with five animals per group. Group 1 served as control while Groups 2 and 5 received 10 mg/kg and 20 mg/kg of quinine respectively 8 hourly for 7 days. Groups 3 received 10 mg/kg of quinine alongside 250 mg/kg of MO extract for 7 days while Group 6 received 20 mg/kg of quinine concomitant with 500 mg/kg of MO leaf extract for 7 days. In Groups 4 and 7, 10 mg/kg and 20 mg/kg of quinine was administered concomitantly with 250 mg/kg and 500 mg/kg respectively for 7 days after which quinine was withdrawn and MO extract continued for another 7 days..............
Keywords: Moringa oleifera, Quinine, Neurotoxicity, Neuroprotection, Inferior Colliculus
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