ISSN: 2249-7781

                    Volume 04 - Issue 01

Welcome to IJPRA! International Journal of Pharmaceutical Research and Applications

Volume 04 - Issue 01     (Jan-June 2019)


Title:
The protective effect of Momordicacharantia L
Authors:
Saed Ayidh Althobaiti
Source:
International Journal of Pharmaceutical Research and Applications, Volume 4, Issue 1 (Jan-June) 2019), PP. 01-07
Abstract:

Diabetes mellitus is the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. Diabetes mellitus is a chronic disorder of the carbohydrate, lipid and protein metabolism that contributes to several kinds of complications including male defective reproductive capacity. In fact, uncontrolled diabetes mellitus is frequently linked with sexual and reproductive dysfunctions in male humans and experimental animals in the form of sterility, erectile dysfunction, reduced libido, semen alterations due to decreased serum androgen levels and impairment of spermatogenesis...............

Keywords:
Hypoglycemic-sterility-a chronic-mellitus-alternative medicine
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Title:
Impact of the aqueous extract of the bark of Sclerocarya birrea on the lipid membrane structure hepatocytes Wistar rats
Authors:
Michodjehoun M. Clementine || Hoteyi Ismael || Ahokpe Melanie || Sossounon Amos || Sezan Alphonse
Source:
International Journal of Pharmaceutical Research and Applications, Volume 4, Issue 1 (Jan-June) 2019), PP. 08-18
Abstract:

The purpose of this study was to evaluate the impact of aqueous extracts of the stem bark of Sclerocarya birrea on the lipid membrane structure of the hepatocytes of Wistar rats. For this, we made the aqueous extraction with the powder of the dried bark of Sclerocarya birrea by the method of Bintou M. (2010). We proceeded to the serum transaminase testing for biochemical examinations then we realized the isolation of rat hepatocytes by cold trypsinization method and lipid extraction drawing inspiration from the method known as solvent gradient used by Stephan et al. (2004) for extracting mycobacterial lipids that has been adapted to the hepatocytes. And finally the impact of aqueous extracts of the barks of Sclerocarya birrea on the lipid membrane structure hepatocytes Wistar rats was assessed by thin layer chromatography of cellular lipids after oral administration of aqueous extracts from barks of Sclerocarya birrea rats Wistar to 50, 100, 200, 300 and 400 mg / Kg.............

Keywords:
Sclerocarya birrea, bark, membran lipid, Benin
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Title:
The relationship between existential anxiety and demoralization syndrome in predicting psychological well-being of people with cancer
Authors:
Bahman Bahmani || Ali Nazeri astaneh || Bahman Rahmani || Bahman Dieji || ElyasNikouyi || Bijan Maghsoudlou Astarabadi || Maede Naghiayi || Shiva Zamaninejad
Source:
International Journal of Pharmaceutical Research and Applications, Volume 4, Issue 1 (Jan-June) 2019), PP. 19-24
Abstract:

Background and Objective: This study aimed to investigate the relationship between existential anxiety and demoralization syndrome in predicting psychological mental wellbeing in people with cancer. Materials and methods:The study employed a correlation research design. 57 patients with cancer (skin, breast, and stomach), 20 to 40 years, referring to hospitals in Ardabil were selected by purposive sampling. The selected individuals completed existential anxiety, demoralization syndrome and psychological well-being Questionnaires. To analyze the data, stepwise regression analysis was used. Results: The results showed that there is a significant negative correlation between the existential anxiety and predicting psychological well-being in people with cancer (p<0/01) and also there is a significant negative correlation between demoralization syndrome and prediction of depression in people with cancer (p <0/01)..........

Keywords:
Existential anxiety, cancer, demoralization
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Title:
Regulatory Guidance for Conducting Clinical Trials in India
Authors:
Ms Ranjini D M || Dr G S Shantha Kumar
Source:
International Journal of Pharmaceutical Research and Applications, Volume 4, Issue 1 (Jan-June) 2019), PP. 25-33
Abstract:

The Central Drugs Standard Control Organization and its administrator Drug Controller general of India (DCGI) are to leave to shield the subjects from the advertising of hazardous medicine. The beginning of the 59threport of the Parliamentary Standing Committee on Health and Family Welfare, have revealed the careless norms (Loose and not effectively held or controlled) trailed by the administrative experts in India. The developing clinical research after the item licenses rights for the pharmaceutical businesses according to the exchange related parts of protected innovation rights assention and unfavorable medication response checking of the advertised medications have raised numerous moral and administrative issues with respect to the advancement of new medications in Indian markets..........

Keywords:
CDSCO, clinical research, drug and cosmetic act, drug and cosmetic rule, drug regulation
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Title:
Opportunities under Biosimilars in India (Emerging Market)
Authors:
Ranjini DM || G. S.Shanthakumar || Sadiq Basha
Source:
International Journal of Pharmaceutical Research and Applications, Volume 4, Issue 1 (Jan-June) 2019), PP. 34-43
Abstract:

In recent years, there are numerous epic biological merchandise are going off patent which has generated an abridged path for the Biosimilars products which relies at the giant comparability attempting out towards Reference Biological Products (RBP) assuring product's great, protection and efficacy.Biosimilars are product much like biologics but not illustrate to them& require excellent advertising and marketing approval with abounding documentation as they are no longer widespread model of biologics. These made regulatory and administrators of several worldwide locations to set up strict stability a number of the fee gain and danger manipulate of the product.Recently India has mounted the biosimilars guideline in June 2012. India has full of life Pharmaceutical Industry for the popular drug at the same time as it could grow to be a rising marketplace for the Biopharmaceutical drug...........

Keywords:
Genetic engineering; Biosimilars; Bio therapeutics product; Marketing surveillance
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